![]() Specifically, they demonstrated the impact of such medications on the MedWise Risk Scores™ (MRS) of various patient populations (Programs of All-Inclusive Care for the Elderly, Medicare, Medicaid and commercially insured), quantified the characteristics of individuals who were at greater risk of adverse drug event (ADEs), and demonstrated the impact of COVID-19 drugs on the risk of drug-induced long QT syndrome . Using proprietary advanced modeling systems, TRHC scientists virtually tested COVID-19 repurposed drugs (e.g., azithromycin, hydroxychloroquine, chloroquine, remdesivir and lopinavir/ritonavir). Key research in 2020 illuminated medication safety issues related to treatments explored during the COVID-19 pandemic. In 2020 alone, this team produced 47 articles that were published in peer-reviewed journals. The Pillar’s clinical pharmacists, clinical research scientists, pharmaceutical scientists, drug information specialists, data scientists, data analysts and software engineers are committed to the development and validation of the TRHC’s systems which improve patient outcomes and reduce preventable healthcare utilization and costs. TRHC’s Research & Development Pillar innovates and redefines the science of medication safety to optimize medication use. TRHC is addressing these medication safety imperatives by developing systems that simplify the medication science to help clinicians reduce inappropriate medication use and to promote and enable safer prescribing.Įxpanding the medication safety knowledge base Too often, medication-related problems originate from drug–drug interactions, multidrug interactions, drug–gene interactions (DGIs), phenotype conversions, and other issues for which explanations are rooted in the deep sciences of pharmacokinetics, pharmacodynamics and pharmacogenomics. Another significant contributor to medication overload is unsafe drug selection. ![]() ![]() The most recognized contributor to this condition of medication overload is excessive prescribing, or overprescribing. Thus, medication overload is predicted to account for at least 4.6 million hospitalizations and 150,000 premature deaths between 20 and will cost taxpayers, patients and families an estimated USD $62 billion if current prescribing trends continue. Nationally, about 40% of older adults take five or more prescription medications, and almost 20% take 10 or more. The Lown Institute attributes medication overload to negative prescribing cultures, knowledge gaps and fragmentation of care due to inadequate communication among providers. Medication overload is a growing problem in the USA. ![]()
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